Dr Mohiuddin previously served as Chief of Transplantation of the Cardiothoracic Surgery Research Program at the National Heart Lung and Blood Institute / the National Institutes of Health (NIH). He held faculty positions at the University of Pennsylvania, Philadelphia, and Rush University, Chicago.

He has been involved in Xenotransplantation Research since 1991 and started xenotransplantation research programs at the NIH, Rush University Chicago, and University of Maryland School of Medicine.

He is Associate Editor for Transplantation and reviews manuscripts for many other journals. He is also the past president of the Dow Graduate Association of North America. Achievements include several NIH and non-NIH grants during his academic career. He is a member of the Community of Transplant Scientists (COTS) executive committee and the advisory council of transplant regenerative medicine of the American Society of Transplantation (AST). He has been elected a the fellow of American Society of Transplantation (FAST). 

Dr. Mohiuddin has devoted his entire career to Xenotransplantation. His contribution to Xenotransplantation includes the demonstration of the most prolonged survival in heterotopic and orthotopic cardiac Xenotransplantation. He is currently President of the International Xenotransplantation Association (IXA) after serving as Councilor for 4 years and as liaison to promote productive dialogue between the IXA and the FDA. He has published over 120 papers, and more than 150 abstracts. Additionally, he has been an invited Xenotransplantation expert speaker on numerous occasions.

His persistence in Xenotransplantation directed him to accomplish the First Genetically Engineered Pig to Human Cardiac Xenotransplantation on January 7, 2022. He also led the 2nd xenotransplantation procedure on September 2023. Both surgeries are performed at the University of Maryland Medical Center, Baltimore, Maryland.

Dr Mohiuddin has been awarded a honorary degree of Doctor of Science (DSC) degree by the Dow University of Health Sciences.

Besides other awards, Dr Mohiuddin was picked by Nature Journal as one of the “Nature’s 10” in 2022. Ten people who helped shape science in 2022.

Dr Mohiuddin was honored by National Geographic Magazine in 2025 in their NatGeo33 issue as one of the 10 Global Visionaries who are Bold leaders pursuing imaginative ideas to make meaningful impact