Dr. Iskandar is recognized for his clinical expertise and experimental work in congenital diseases that alter CSF hydrodynamics, in particular hydrocephalus, Chiari malformations, and syringomyelia. Led by Dr. Iskandar and funded by the Theodore W. Batterman Family Foundation, the Wisconsin Hydrocephalus Group (WHP) of engineers, physicists, neurologists, and neurosurgeons aims to determine the etiology of ventricular shunt malfunction and optimize the devices used to treat it. As well, Dr. Iskandar directs a translational research laboratory previously funded by the NIH and the March of Dimes that has discovered an important link between single carbon folate and cobalamin metabolism, epigenetic influences, and axonal regeneration after central nervous system injury. Dr. Iskandar has served on national neurosurgical committees and boards, and currently serves as Immediate Past Chair of the Board of Directors of the American Board of Pediatric Neurological Surgery and as Immediate Past Chair of the AANS/CNS Section on Pediatric Neurosurgery.