1. Appreciate the findings & clinical practice implications of the Kids-DOTT multicenter trial for VTE treatment in children, 2. Appreciate advantages of the parallel-cohort RCT design as applied to rare diseases/ low-frequency conditions, 3. Understand endpoint quality assurance measures critical to maximizing “signal-to-noise” in clinical trials, and 4. Discuss the findings from pilot data and implications for VTE treatment in children with cardiac disease