After this Virtual Grand Round, participants should be able to: (1) Describe the relevant ethical, legal, and practical implications associated with decisional capacity when treating or conducting research with minors. (2) Provide a framework for assessing the decisional capacity of minors in clinical and research settings. (3) Present a model for balancing the autonomy rights of minors with their need for protection using information about decisional capacity. [Recorded 04/09/2021]