After this Virtual Grand Round, participants should be able to: 1. Describe the epidemiology of substance use-related harm in the US, with a focus on adolescents and young adults (“youth”), 2. Prescribe opioids in a manner that reduces the likelihood of risk for long-term opioid use and addiction, and 3. Ensure evidence-based screening and treatment for youth with substance use disorders [Recorded 11/10/2023]